The 10th meeting of the Federation of Clinical Immunology Societies (FOCIS) was held in Boston during 23-27 June 2010. As usual, this conference highlights the greatest advancements in the field of clinical immunology over the previous year. It is especially remarkable since this is the 10th meeting and many programs were set up to celebrate this decade of FOCIS meetings. Two of the FOCIS founders, Drs Garrison Fathman and David Hafler, made special lectures in FOCIS Founder Symposium and both speakers emphasized that FOCIS provides a platform for clinicians and scientists to meet to discuss the commonalities of immune-based diseases. They expressed their belief that advances in immune-based pathophysiology can be encompassed by the five pillars of FOCIS: immunoregulation, immunogenetic/genomics, immunotherapy, immunodiagnosis/immune monitoring and host defense. More than 450 participants attended the meeting, which comprised 4 keynote addresses, 60 plenary lectures and 94 selected oral presentations. In addition, 344 posters were presented to an interested audience.